lunedì 23 aprile 2018

Utilizzo terapeutico degli U.S.


High intensity focused ultrasound technology, its scope 

and applications in therapy and drug delivery.


Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of 
producing real-time non-invasive images without significant biological effects. 
However, the propagation of higher energy, intensity and frequency ultrasound 
waves through living tissues can induce thermal, mechanical and chemical 
effects useful for a variety of therapeutic applications. With the recent development 
of clinically approved High Intensity Focused Ultrasound (HIFU) systems,
 therapeutic ultrasound is now a medical reality. Indeed, HIFU has been 
used for the thermal ablation of pathological lesions; localized, minimally 
invasive ultrasound-mediated drug delivery through the transient formation 
of pores on cell membranes; the temporary disruption of skin and the blood 
brain barrier; the ultrasound induced break-down of blood clots; and the 
targeted release of drugs using ultrasound and temperature sensitive 
drug carriers. This review seeks to engage the pharmaceutical research 
ùcommunity by providing an overview on the biological effects of 
ultrasound as well as highlighting important therapeutic applications, current 
deficiencies and future directions.

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